Ruling as South India’s most advanced genomics laboratory does not come only from our sequencing services. Our lab provides every vital support required to probe into the vast field of genomics and support our clients in simple or complex research projects. We make this possible by offering molecular services that examine the fine nuances of genomics.
Molecular genomics is a critical component that adds crucial elements to the expanding DNA / RNA analysis database, their link with diseases, disease prognosis, and therapeutic response. At Yaazh Xenomics, we offer a slew of molecular services to support extensive clinical research to diagnose diseases to establish a connection to the patient’s genetic profile.
Our highly reliable transcript services provide invaluable post-research support with the finest proofreading and editing for research paper publication, PhD thesis, dissertation, and college projects.
We enhance the clarity and coherence of your thesis by working on the language style, structure, and presentation. Our thesis editing is what you need to enhance the marketing criteria of your thesis.
We enhance the clarity and coherence of your thesis by working on the language style, structure, and presentation. Our thesis editing is what you need to enhance the marketing criteria of your thesis.
We are a one-stop shop for expert support in protein and cell analysis, immunology, and molecular biology. Our collaboration with global leaders allows us to offer customised services for academic, clinical, and diagnostic research.
We deploy the finest molecular technology to develop DNA markers with Randomly Amplified Polymorphic DNA, a PCR-based technique. Our technique is a powerful method of analysis in detecting genetic diversity.
Yaazh offers in-depth AFLP techniques to assess genetic diversity within species, to deduce biogeographic patterns and phylogenies, generate genetic maps, and detect various polymorphisms.
We use restriction enzymes to create DNA fragments for Terminal Restriction Fragment Length Polymorphism. All DNA fragments are labelled with a fluorescent molecule and separated by Gel Electrophoresis.
Flip through international journals that delve deep into cellular, functional and molecular aspects of therapy. The journals help you understand the mechanisms clearly and detect the elements that can directly influence human health.
We offer you a comprehensive set of proteomic services that include peptide synthesis, protein purification, protein Identification, protein profiling, 2D electrophoresis, clinical protein electrophoresis, and protein expression.
PCR product analysis involves evaluating the results of Polymerase Chain Reaction (PCR) to confirm amplification, assess product size, and quantify DNA or RNA targets. This service ensures the quality and integrity of your PCR experiments for downstream applications.
GMO detection involves identifying the presence of genetically modified organisms in food, feed, or environmental samples using advanced molecular techniques. This service ensures compliance with regulatory standards and provides transparency regarding product composition.
Restriction digest analysis is a molecular biology technique used to cut DNA at specific recognition sites using restriction enzymes, enabling fragment size determination and genetic mapping. This service is crucial for cloning, genotyping, and DNA fingerprinting applications.
Gene expression analysis measures the activity of genes by quantifying RNA or protein products, providing insights into cellular processes, disease mechanisms, and therapeutic responses. This service helps researchers understand which genes are turned on or off in different conditions.
Detection of low levels of RNA is a specialized service employing highly sensitive techniques to accurately quantify minute quantities of RNA, crucial for studies involving rare transcripts or limited sample availability. This ensures reliable results even from challenging samples.
Analysis of total RNA involves assessing the quantity and quality of all RNA molecules within a sample, including mRNA, rRNA, and tRNA. This crucial step ensures the integrity of RNA samples for downstream applications like sequencing or gene expression studies.
Analysis of Cy5 labelled samples involves detecting and quantifying molecules tagged with the Cy5 fluorescent dye, commonly used in microarray experiments, fluorescence microscopy, and flow cytometry. This service provides precise data on labelled biomolecules.
Ribosomal RNA (rRNA) contamination in mRNA samples is a common issue that can interfere with downstream applications like RNA sequencing. Our service accurately quantifies and helps mitigate rRNA contamination to ensure high-quality mRNA data for your research.
Analysis of RNA transcripts involves studying the individual RNA molecules produced from gene expression, including their quantity, splicing variants, and modifications. This service provides crucial insights into gene regulation and cellular function.
Optimisation of protein purification involves refining protocols to achieve higher yields and purity of target proteins, essential for structural and functional studies. Our experts develop tailored strategies to enhance your protein purification efficiency.
Protein expression is the process by which proteins are synthesized, modified, and regulated within living organisms or cell-free systems. Our service offers comprehensive solutions for expressing recombinant proteins in various host systems for research and therapeutic applications.
Antibody analysis involves characterizing antibodies for specificity, affinity, and concentration, crucial for their use in diagnostics, therapeutics, and research. Our services ensure the quality and performance of your antibody reagents.
Fast analysis of proteins between 5-50 kDa utilizes rapid and efficient methods to characterize proteins within this specific molecular weight range, crucial for quick assessment in various proteomic studies. This service delivers timely results for your research.
Analysis of protein purification involves assessing the purity, concentration, and integrity of proteins after purification steps, using techniques like SDS-PAGE, Western blot, or mass spectrometry. This ensures the quality of your purified protein for downstream experiments.
Human and mammalian cell culture involves the growth and maintenance of human and other mammalian cells under controlled conditions for various research applications, including drug discovery, disease modeling, and vaccine production. We provide expert cell culture services.
Slide making involves the preparation of high-quality microscopic slides from biological samples for histological, cytological, or molecular analysis. Our service ensures precise sectioning, staining, and mounting for accurate microscopic examination.
Chromosome harvesting is a critical step in cytogenetic analysis, involving the isolation and preparation of chromosomes from dividing cells for karyotyping and other chromosomal studies. Our service ensures high-quality metaphase spreads for accurate analysis.
Characterizing tumour-related cell lines for chromosome rearrangement involves detailed cytogenetic analysis to identify structural and numerical chromosomal abnormalities. This service is crucial for understanding cancer progression, drug resistance, and developing targeted therapies.
Special studies using a variety of banding techniques, including G, C, and R, are performed to visualize specific chromosomal regions and identify structural abnormalities with high resolution. These techniques are essential for detailed karyotyping and genetic diagnostics.
Standard metaphase analyses with G-banding technique involve examining chromosomes during metaphase after G-banding to identify numerical and structural chromosomal aberrations. This is a fundamental method for clinical cytogenetics and genetic diagnostics.
Potential DNA damage refers to alterations in the DNA structure that can lead to mutations, cell death, or cancer. Our services assess various forms of DNA damage using specialized assays to evaluate genotoxicity and genomic stability.
Chromosomal aberrations such as breaks, gaps, large deletions, dicentrics, chromosomal fragmentations, and complex rearrangements are structural changes in chromosomes that can lead to genetic disorders or cancer. Our cytogenetic analysis services accurately detect and characterize these abnormalities.
The study of chromosomal instability or aberrations due to radiation or mutagen treatments involves assessing the impact of genotoxic agents on genomic integrity. Our services utilize advanced cytogenetic techniques to evaluate induced chromosomal damage and instability.
Cell Viability (MTT), Cell Proliferation (BrdU), and Cell Survival (Bcl/Bax/NFKB) assays are crucial for assessing cellular health, growth, and response to treatments. Our services provide accurate measurements of these parameters to support your cell biology research.
An Apoptosis Assay measures programmed cell death, a fundamental biological process, using various techniques such as Annexin V staining, caspase activity, or DNA fragmentation analysis. This service helps researchers study cell fate and disease mechanisms.
Cytotoxicity Assays (MMTT / TXT / MTS / NRU / NHK- NRU) measure the toxic effects of compounds on cells, assessing cell viability and proliferation. These assays are vital for drug screening, toxicology studies, and evaluating the safety of various substances.
Genotoxicity Assays (SSCE / NOR / AgNOR / COMET) evaluate the ability of a substance to cause damage to genetic material, which can lead to mutations or cancer. These assays are crucial for safety assessments in pharmaceutical and chemical industries.
Cell Cycle Progression analysis, often involving markers like CDK2, CDK4, and p53, investigates the phases of cell growth and division. This service is critical for understanding cell proliferation, differentiation, and the mechanisms of cancer and other diseases.
Brine Shrimp Lethality (in vivo) assay is a rapid and cost-effective method for preliminary toxicity screening of various compounds. This assay uses Artemia salina larvae to assess the general toxicity of natural products and synthetic chemicals.
DPPH radical scavenging assay is a common method used to evaluate the antioxidant activity of compounds by measuring their ability to neutralize the stable DPPH radical. This service helps quantify the free radical scavenging potential of various samples.
Superoxide anion scavenging (PMS-NADH system) assay measures the ability of compounds to neutralize superoxide radicals generated by the PMS-NADH system. This service is crucial for evaluating the antioxidant capacity against one of the most common reactive oxygen species.
ABTS radical scavenging assay is a spectrophotometric method used to determine the total antioxidant capacity of samples by measuring their ability to scavenge the ABTS radical cation. This service provides a robust measure of antioxidant potential.
Nitric-oxide scavenging assay measures the ability of compounds to inhibit nitric oxide production or directly scavenge nitric oxide radicals. This service is important for evaluating anti-inflammatory and antioxidant properties of various substances.
ORAC (Oxygen Radical Absorbance Capacity) hydrophilic assay measures the antioxidant capacity of water-soluble compounds against peroxyl radicals. This service quantifies the ability of hydrophilic antioxidants to protect against oxidative damage.
Hydroxyl radical scavenging assay measures the ability of compounds to neutralize highly reactive hydroxyl radicals, which are potent initiators of oxidative damage. This service helps assess the protective effects of antioxidants against severe oxidative stress.
P70S6 kinase inhibition assays measure the ability of compounds to block the activity of p70S6 kinase, a key enzyme involved in cell growth and proliferation. This service is vital for drug discovery targeting cancer and metabolic diseases.
Glucose-6-Phosphatase inhibition assays measure the ability of compounds to block the activity of Glucose-6-Phosphatase, a key enzyme in glucose homeostasis. This service is crucial for drug discovery targeting diabetes and other metabolic disorders.
Alpha-Glucosidase inhibition assays measure the ability of compounds to block the activity of alpha-glucosidase, an enzyme involved in carbohydrate digestion. This service is crucial for screening potential anti-diabetic agents that reduce post-meal glucose spikes.
IKK-β (NF-κB kinase) inhibition assays measure the ability of compounds to block the activity of IKK-β, a crucial enzyme in the NF-κB signaling pathway involved in inflammation and immune responses. This service is vital for developing anti-inflammatory drugs.
PTP-1B inhibition assays measure the ability of compounds to block the activity of Protein Tyrosine Phosphatase 1B (PTP-1B), an enzyme implicated in insulin resistance and obesity. This service is crucial for screening potential anti-diabetic and anti-obesity agents.
Alpha-Amylase inhibition assays measure the ability of compounds to block the activity of alpha-amylase, an enzyme involved in starch digestion. This service is crucial for screening potential anti-diabetic agents that reduce post-meal glucose spikes.
Malondialdehyde (MDA) inhibition assays measure the ability of compounds to reduce the formation of MDA, a common biomarker of lipid peroxidation and oxidative stress. This service helps evaluate the antioxidant and protective effects of various substances.
Aldose Reductase inhibition assays measure the ability of compounds to block the activity of Aldose Reductase, an enzyme involved in the polyol pathway linked to diabetic complications. This service is crucial for screening potential therapeutic agents for diabetes.
Na+ - K+ - ATPase activity assays measure the function of the sodium-potassium pump, a critical enzyme responsible for maintaining ion gradients across cell membranes. This service is vital for studying cellular physiology, drug effects, and disease mechanisms.
Anti-inflammatory / Anti Allergy Assays
Trypsin inhibition assays measure the ability of compounds to block the activity of trypsin, a serine protease involved in protein digestion and various physiological processes. This service is crucial for screening potential anti-inflammatory or anti-coagulant agents.
Histamine release using RBL-2H3 cells is an in vitro assay used to evaluate the allergic potential of compounds by measuring their ability to induce histamine secretion from mast cells. This service is crucial for screening anti-allergic and anti-inflammatory agents.
Nitric Oxide scavenging assay measures the ability of compounds to inhibit nitric oxide production or directly scavenge nitric oxide radicals. This service is important for evaluating anti-inflammatory and antioxidant properties of various substances.
HRBC membrane stabilisation assay measures the ability of compounds to protect human red blood cell membranes from lysis induced by hypotonic solutions or heat. This service is used to evaluate the anti-inflammatory and membrane-protective properties of various agents.
15-Lipoxygenase inhibition assays measure the ability of compounds to block the activity of 15-Lipoxygenase, an enzyme involved in the synthesis of inflammatory mediators. This service is crucial for screening potential anti-inflammatory and anti-allergic agents.
PLA2 inhibition assays measure the ability of compounds to block the activity of Phospholipase A2 (PLA2), an enzyme involved in the release of inflammatory mediators from cell membranes. This service is crucial for screening potential anti-inflammatory agents.
LTB4 release assays measure the production and secretion of Leukotriene B4 (LTB4), a potent inflammatory mediator, from activated immune cells. This service is crucial for evaluating the anti-inflammatory properties of compounds and understanding immune responses.
Elastin release using IMR-90 cells is an assay that measures the degradation and release of elastin, a key component of the extracellular matrix, from lung fibroblast cells. This service is important for studying tissue remodeling, aging, and lung diseases.
Hyaluronidase inhibition assays measure the ability of compounds to block the activity of hyaluronidase, an enzyme that degrades hyaluronic acid, a key component of the extracellular matrix. This service is crucial for screening anti-inflammatory and anti-aging agents.
Elastase inhibition assays measure the ability of compounds to block the activity of elastase, a protease that degrades elastin and other extracellular matrix proteins. This service is crucial for screening agents targeting inflammatory diseases and tissue damage.
Collagenase inhibition assays measure the ability of compounds to block the activity of collagenase, an enzyme that degrades collagen, the most abundant protein in the extracellular matrix. This service is crucial for screening agents targeting fibrosis, arthritis, and cancer.
Collagen release using NIH-3T3 cells is an assay that measures the degradation and release of collagen, a key component of the extracellular matrix, from fibroblast cells. This service is important for studying tissue remodeling, wound healing, and fibrotic diseases.
Time-Kill kinetics assays measure the rate and extent of microbial killing by an antimicrobial agent over time. This service is crucial for evaluating the bactericidal or fungicidal activity of new drugs and disinfectants.
Resazurin Assay (Microtitre-plate) is a colorimetric assay used to assess cell viability, proliferation, or microbial growth in a high-throughput format. This service provides a sensitive and reliable method for screening compounds and evaluating cellular responses.
Anti-Bacterial / Fungal Susceptibility (MIC50 or MIC90) assays determine the minimum concentration of an antimicrobial agent required to inhibit the growth of 50% or 90% of microbial strains. This service is essential for drug development and resistance monitoring.
An Antibiotic susceptibility test or Antibiogram determines the effectiveness of various antibiotics against specific bacterial strains. This service is crucial for guiding clinical treatment decisions and monitoring antibiotic resistance patterns.
The Post-Antibiotic Effect (PAE) refers to the persistent suppression of bacterial growth after a brief exposure to an antibiotic. Our service measures PAE to provide insights into optimal dosing regimens and treatment strategies for infectious diseases.
Yaazh Xenomics is a leading biotechnology company based in Coimbatore, Tamil Nadu, India, specializing in comprehensive genomic solutions. As a DNA testing laboratory, we offer a broad spectrum of services, including DNA sequencing, RNA Sequencing, Sanger Sequencing, 16s rRNA, 18s rRNA, ITS, COI, RBCL, Matk gene Sequencing for DNA Barcoding, gene expression analysis, SNP analysis, Next-Generation Sequencing (NGS), Various Medical Genome testing, Exome Sequencing, Gut Microbiome Test, Metagenome Sequencing, Whole Genome Sequencing (WGS), Transcriptome Sequencing using advance NGS platforms like Nanopore, Illumina, MGI, Thermo. Also, we provide advance Bioinformatics, Customized Bioinformatics and a variety of other genetic testing and Molecular testing.