Whole Genome Sequencing determines the exact order of nucleotides (A, T, C, G) across the entire genome of an organism — including coding regions, regulatory elements, introns, and non-coding DNA. Unlike targeted panels or exome sequencing, WGS provides an unbiased, base-by-base view, making it the gold standard for comprehensive genomic analysis.

Modern WGS combines high-throughput Next-Generation Sequencing (NGS) platforms with advanced bioinformatics pipelines to detect even the most complex genetic variations that other methods might miss.

Types of Whole Genome Sequencing We Offer

1. De Novo Whole Genome Sequencing

Ideal when no reference genome exists. Our de novo sequencing services generate high-quality reference genomes for novel species, strains, or uncharacterized organisms. Using a combination of short-read (Illumina) and long-read (Nanopore) technologies, we achieve superior contiguity, completeness, and accuracy in genome assembly.

Key Benefits: Detection of large structural variants such as inversions, translocations, duplications, and deletions.

2. Whole Genome Resequencing

Compares an individual’s or sample’s genome against a known reference genome to identify genetic differences. This approach is widely used for population studies, disease research, and breeding programs.

We excel at detecting:

• Single Nucleotide Polymorphisms (SNPs)
• Insertions and Deletions (Indels)
• Copy Number Variations (CNVs)
• Structural Variants (SVs)
• Somatic mutations
• Rare and low-frequency variants

Advanced Platforms & Technologies at Yaazh Xenomics

We utilize multiple cutting-edge sequencing platforms to match your project requirements:

• Illumina NovaSeq Series — Ultra-high throughput, exceptional accuracy for deep coverage resequencing
• Oxford Nanopore Technology — Long-read sequencing (up to hundreds of kb) for resolving complex regions, repeats, and structural variants
• MGI Sequencing Platform — Cost-effective, high-quality short-read sequencing
• Thermo Fisher Ion S5 Plus — Flexible semiconductor-based sequencing for targeted or smaller genome projects

Our specialty is hybrid sequencing — integrating short-read accuracy with long-read contiguity for the most complete and reliable genome assemblies and variant calls.

End-to-End Whole Genome Sequencing Workflow

• High-quality DNA extraction from diverse sample types (blood, tissue, microbes, plants, environmental samples)
• Library preparation with optimized protocols for short-read and long-read sequencing
• Sequencing on multiple platforms with customizable coverage depth (30x–100x+)
• Advanced bioinformatics analysis: Quality control, assembly, alignment, variant calling, annotation, and functional interpretation
• Customized reporting with publication-ready figures, phylogenetic analysis, and comparative genomics

Applications of Our Whole Genome Sequencing Services

• Discovery of novel genes and rare disease-causing variants
• Microbial genomics and pathogen genome sequencing
• Plant and animal breeding / agricultural genomics
• Cancer genomics and somatic mutation profiling
• Population genetics and evolutionary studies
• Metagenomics and microbiome research support
• CRISPR editing validation and off-target analysis
• Pharmacogenomics and personalized medicine research
• Food safety, environmental monitoring, and industrial strain improvement

Why Choose Yaazh Xenomics for Whole Genome Sequencing?

• Expert team with deep experience in hybrid short + long-read genome assembly
• High data quality with stringent QC standards and comprehensive bioinformatics support
• Flexible project customization — from low to ultra-high coverage
• Competitive pricing with fast turnaround times
• One-stop genomic solution integrating WGS with RNA-Seq, metagenomics, Sanger validation, and more
• Secure data handling and detailed, easy-to-understand reports
• Pan-India service with dedicated support for academic, biotech, pharma, and clinical researchers