Yaazh Xenomics provides comprehensive Epigenome Sequencing services to investigate heritable changes in gene expression that do not involve alterations in the underlying DNA sequence. From our advanced genomics facility in Coimbatore (with support across India including Visakhapatnam), we deliver high-resolution insights into DNA methylation, histone modifications, chromatin accessibility, and non-coding RNA regulation using cutting-edge Next-Generation Sequencing (NGS) technologies.
Our epigenomics solutions help researchers understand gene regulation, development, disease mechanisms, environmental responses, and personalized medicine — delivering accurate, publication-ready data with robust bioinformatics analysis.
The epigenome consists of chemical modifications and proteins that regulate gene activity without changing the DNA sequence itself. Epigenome sequencing (epigenomics) uses NGS to map these modifications genome-wide, revealing how cells control gene expression in health and disease.
Key epigenetic mechanisms include:
The gold-standard method for single-base resolution DNA methylation profiling across the entire genome. WGBS detects 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) by converting unmethylated cytosines to uracil while preserving methylated ones.
Applications: Global methylation patterns, differentially methylated regions (DMRs), cancer epigenetics, developmental biology, and environmental toxicology.
A cost-effective, targeted approach that enriches CpG-rich regions (promoters, CpG islands) using restriction enzymes followed by bisulfite conversion. Ideal when full WGBS depth is not required or budget is a constraint.
Advantages: High coverage of regulatory regions with significantly lower sequencing cost and data volume.
Maps genome-wide protein-DNA interactions and histone modifications. We perform ChIP-Seq for transcription factors, histone marks (H3K4me3, H3K27ac, H3K27me3, etc.), and other chromatin-associated proteins.
Key Outputs: Peak calling, motif analysis, enhancer/promoter identification, and integration with RNA-Seq data.
A fast, sensitive method to profile open chromatin regions using Tn5 transposase. ATAC-Seq requires minimal input material and provides high signal-to-noise ratio for identifying active regulatory elements, nucleosome-free regions, and transcription factor binding sites.
Variants: Bulk ATAC-Seq and single-cell ATAC-Seq (scATAC-Seq) for cellular heterogeneity studies.
Contact our epigenomics specialists for a free consultation, project design recommendations, or a customized quote.
Phone: +91 99431 32020 | +91 95002 45454
Email: info@yaazhxenomics.com
Coimbatore Laboratory:
Module No. 103, TICEL BIOPARK Phase – III, 1st Floor,
Maruthamalai Road, Coimbatore - 641046, Tamil Nadu, India
Visakhapatnam Office:
No.9-6, Sritej Nagar, Anandapuram, Visakhapatnam - 531022, Andhra Pradesh
Unlock the regulatory code of the genome with precise Epigenome Sequencing from Yaazh Xenomics — your trusted NGS partner in India.
Yaazh Xenomics — Delivering high-resolution Epigenome Sequencing (WGBS, RRBS, ChIP-Seq, ATAC-Seq) with expert bioinformatics for groundbreaking research in epigenetics and gene regulation across India.